Volume 2 - Issue 2, March - April 2026

Psychotic disorders such as schizophrenia impose a substantial burden on patients and healthcare systems worldwide. Although conventional antipsychotic drugs are effective in managing symptoms, their prolonged use is often limited by serious adverse effects, including extrapyramidal symptoms and metabolic disturbances. This has stimulated interest in medicinal plants as alternative or complementary therapeutic agents. Withania coagulans, a plant traditionally used in indigenous systems of medicine, has been reported to possess antioxidant, anti-inflammatory, and central nervous system–modulating properties. The present study was designed to evaluate the antipsychotic potential of Withania coagulans using experimental animal models. An alcoholic extract prepared from the fruits of the plant was administered orally to Swiss albino mice at doses of 200 mg/kg, 500 mg/kg, and 1000 mg/kg. Antipsychotic activity was assessed using the Conditioned Avoidance Response (CAR) test, a widely accepted screening model for antipsychotic agents. Behavioural responses were recorded and statistically analyzed. The results demonstrated that the extract did not produce a significant suppression of avoidance behavior when compared to the control group. These findings indicate that Withania coagulans fruit extract does not exhibit marked antipsychotic activity under the experimental conditions employed. However, the presence of bioactive phytoconstituents suggests that further investigations using different plant parts, extraction techniques, and experimental models are warranted.

Vaishnavi K. Bhosle, Dr. Ganesh R. Phadtare , Dr Sanjay Arote, Vaishnavi Patil,"Review of Antipsychotic Activity of Withania Coagulans" International Journal of Advanced Multidisciplinary Research and Educational Development, V2(2): Page(444-448) Mar-Apr 2026. ISSN: 3107-6513. www.ijamred.com. Published by Scientific and Academic Research Publishing.