This paper explores how the ancient Hindu philosophical text, the Bhagavad Gita, can inform multidisciplinary approaches to sustainable development in the face of contemporary disruptive change. The Gita, a synthesis of Upanishadic wisdom, offers a profound ethics of action (karma yoga), emphasizing selfless engagement, resilience, and interdependence, which provides a valuable framework for navigating global uncertainties like technological advancement and environmental degradation. By integrating insights from philosophy and recent advances in artificial intelligence (AI), specifically Natural Language Processing (NLP) and deep learning, scholars have conducted computational analyses—including topic modeling, sentiment analysis, and semantic comparison—of the Gita and the Upanishads. These studies validate the traditional claim that the Gita encapsulates the Upanishads’ essence and reveal both the robustness of its core philosophical messages across translations and the limitations of current machine translation for philosophically complex, low-resource languages like Sanskrit. The findings underscore the potential of AI to facilitate interdisciplinary dialogue and the need for culturally sensitive technologies and human expertise in global sustainability initiatives. Ultimately, the Gita’s teachings on ethical resilience and ecological consciousness, interpreted through a multidisciplinary lens, offer a roadmap for ethical leadership and adaptive action toward a more sustainable and equitable future.