This article examines the origins of life using an interdisciplinary approach, combining the perspectives of the Qur'an and chemistry, particularly the Oparin-Haldana theory of chemical evolution. This study is motivated by the need to integrate science and revelation to address modernist accusations that religion is irrelevant to scientific development. This research uses a qualitative method with a literature review, collecting data from classical interpretations, scientific literature, and modern research. The results show that the Qur'an emphasizes water as the source of life, as stated in Surah al-Anbiya' verse 30, al-Baqarah verse 164, and an-Nur verse 45. This view aligns with the Oparin-Haldana theory, which explains that chemical elements in Earth's early atmosphere reacted to form organic compounds through the role of water and energy. Furthermore, research by Daly et al. (2021) strengthens this theory by finding that water can also originate from asteroid particles exposed to the solar wind. Thus, both the Qur'an and modern science demonstrate conceptual harmony that water is a fundamental element for the birth of life, although they differ in their explanatory mechanisms. This study emphasizes the importance of an interdisciplinary approach in understanding the relationship between revelation and modern science.