Volume 2 - Issue 1, January - February 2026

The delivery of drugs through the buccal mucosa has received a great deal of attention over the last two decades, and yet there are not many buccal delivery products available on the market. The buccal route offers an attractive alternative for systemic drug delivery of drugs studies of oral cavity absorption were first reported in 1935. Since then, substantial effort has been focused on drug absorption from a drug delivery system in a particular region of the oral cavity3. because of better patient compliance, ease of dosage form removal in emergencies, robustness, and good accessibility. Use of buccal mucosa for drug absorption was first attempted by Sobrero in 1847, and since then much research was done to deliver drugs through this route. The oral mucosa provides a protective covering for the underlying tissue, being as a barrier for microorganisms and toxins. This article extensively reviews the anatomy and physiology of buccal mucosa, buccal drug delivery system andtheir components, theories, factors affecting drug absorption through buccal mucosa and evaluation.

Ch.Naga Sowjanya, D.Rama Brahma Reddy, S.Vyshnavi,"Mucoadhesive Buccal Delivery System" International Journal of Scientific Research and Engineering Development, V2(1): Page(154-163) Jan-Feb 2026. ISSN: 3107-6513. www.ijamred.com. Published by Scientific and Academic Research Publishing.