Volume 2 - Issue 2, March - April 2026

Liposomes are microscopic, spherical vesicles composed of one or more phospholipid bilayers enclosing an aqueous core. Since their discovery in the 1960s, they have emerged as one of the most successful and versatile platforms for drug delivery. Their unique structure allows them to encapsulate both hydrophilic (water-soluble) and lipophilic (fatsoluble) drugs, protecting them from degradation, improving their solubility, and modifying their pharmacokinetic profile. Liposomal formulations can reduce the systemic toxicity of potent drugs, extend their circulation time, and enable targeted delivery to specific tissues, such as tumors, via passive or active mechanisms. This review explores the fundamental structure of liposomes, their advantages and disadvantages, key manufacturing challenges, and their successful translation into clinically approved products. We also discuss recent advancements and future perspectives, including the development of "smart" liposomes and their expanding role in gene therapy and vaccines.

Miss. More Mansi Chakradhar, Miss. Rohini Holkunde, Dr.Ganesh.S. Tolsarwad,"Liposome: A Drug Delivery System" International Journal of Advanced Multidisciplinary Research and Educational Development, V2(2): Page(984-998) Mar-Apr 2026. ISSN: 3107-6513. www.ijamred.com. Published by Scientific and Academic Research Publishing.