Volume 2 - Issue 2, March - April 2026

Nanocochleates are an innovative drug-delivery system in which the drug is enclosed within a spiral, multilayered solid-lipid structure. This unique arrangement protects the drug from harmful environmental factors and increases its stability. Because these carriers contain both hydrophilic and lipophilic components, they can transport a variety of drugs. They can be prepared using different techniques and are useful in several medical applications. Owing to their strong protective ability and fewer limitations than many traditional dosage forms, nanocochleates are considered a highly promising and effective method for drug delivery. Nanocochleates are advanced lipid-based carriers where charged drug molecules are packed inside a spiral, multilayered solid-lipid system. They safeguard the drug from harsh external conditions and can successfully carry water-soluble or charged molecules. These structures form through interactions between negatively charged lipids and positively charged drugs or peptides, and the particle size can be controlled by adjusting the charge ratio. This method, called hydrogel cochleation, produces stable, submicron-sized particles with minimal limitations, making nanocochleates a strong option for safe and efficient oral drug delivery.Nanocochleates represent a modern lipid-based system suitable for both oral and systemic administration. They can transport a wide range of therapeutic substances, including drugs, genes, and vaccines. This delivery method is especially beneficial for molecules with poor oral bioavailability or drugs that are hydrophobic or charged. Nanocochleates help enhance the stability and absorption of such drugs, providing an alternative to injectable routes. Current animal studies further highlight their potential for effective oral delivery of essential medications.

Kolhe Shruti Madhavrao, Anjali More,"Nanocochlates : A Novel Drug Delivery System" International Journal of Advanced Multidisciplinary Research and Educational Development, V2(2): Page(1350-1376) Mar-Apr 2026. ISSN: 3107-6513. www.ijamred.com. Published by Scientific and Academic Research Publishing.