Volume 2 - Issue 2, March - April 2026

Facial rejuvenation has gained substantial prominence in contemporary clinical practice, particularly with the widespread use of botulinum toxin type A due to its well-established neuromuscular blocking effects and favorable safety profile. However, the emergence of COVID-19, caused by SARS-CoV-2, has introduced new challenges regarding potential interactions between infection, vaccine-induced immune responses, and aesthetic procedures. Current evidence suggests that these immunological alterations may influence the therapeutic response to botulinum toxin, potentially affecting its duration and clinical efficacy. In this context, this study aims to analyze the possible interactions between SARS-CoV-2 infection, COVID-19 vaccination, and the effects of botulinum toxin type A. The findings indicate that immune activation, inflammatory mediators, and antibody production may act as modifying factors in treatment outcomes. These results highlight the importance of a cautious and individualized clinical approach, as well as the need for further scientific investigation to better understand these interactions.

Thauann Lima Silva Rufino,"Impacts of SARS-CoV-2 Infection and COVID-19 Vaccination on the Duration of Botulinum Toxin Effects: A Review of the Evidence" International Journal of Advanced Multidisciplinary Research and Educational Development, V2(2): Page(1565-1569) Mar-Apr 2026. ISSN: 3107-6513. www.ijamred.com. Published by Scientific and Academic Research Publishing.