Volume 2 - Issue 2, March - April 2026

Inflammation is a pathological condition underlying many chronic diseases including arthritis, cardiovascular disorders, and autoimmune illnesses. Traditional medicines have long used Fagonia indica for its therapeutic benefits, but scientific validation remains limited. This study evaluates the anti-inflammatory potential of Fagonia indica methanolic extract using in vivo animal models. Carrageenan-induced paw edema and cotton pellet–induced granuloma models were used in Wistar rats. The extract demonstrated significant inhibition (p < 0.05) of acute and chronic inflammation comparable to the standard reference drug, diclofenac sodium. Biochemical markers including reduced levels of pro-inflammatory cytokines further supported the extract’s effect. These findings suggest that Fagonia indica has appreciable anti-inflammatory activity and merits further phytochemical isolation studies for potential drug development.

Vaishnavi Patil, Dr.Ganesh R. Phadtare , Dr.Sanjay Arote, Vaishnavi Bhosle,"Review of Anti-Inflammatory Activity of Fagonia indica in Experimental Animal Models" International Journal of Advanced Multidisciplinary Research and Educational Development, V2(2): Page(483-487) Mar-Apr 2026. ISSN: 3107-6513. www.ijamred.com. Published by Scientific and Academic Research Publishing.